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Alpha Analytical's experienced staff has written and/or collaborated with several industry consultants to publish a number of environmental technical reports and presentations on various contaminants and analytical methods.
A synopsis of each technical report is noted below.
Bypassing the TPH-dependent hydroxylation step with the administration of 5-hydroxytryptophan restored 5-HT to control levels and prevented the deleterious effects of PCB on the neuroendocrine parameters.
Moreover, slow-release Gn RH implants prevented the PCB-induced decline in Gn RH receptors and restored the LH response to Gn RHa, suggesting that Gn RH therapy can reverse PCB-induced disruption of LH secretion.
The maximum allowable contaminant level in drinking water in the United States is set at zero, but because of the limitations of water treatment technologies, a level of 0.5 parts per billion is the de facto level.
Other physical and chemical properties vary widely across the class.
They can generate extremely toxic dibenzodioxins and dibenzofurans through partial oxidation.
These results demonstrate that TPH is one of the targets of PCB neurotoxicity and indicate that a decrease in 5-HT availability in PCB-exposed croaker results in disruption of the stimulatory 5-HT/Gn RH pathway controlling LH secretion.
Considerable evidence suggests that a variety of endocrine disrupting chemicals, such as heavy metals, pesticides, and polychlorinated biphenyls (PCBs), can impair vertebrate reproduction by acting at the hypothalamic level [1–9].
Intentional degradation as a treatment of unwanted PCBs generally requires high heat or catalysis (see Methods of destruction below).
PCBs readily penetrate skin, PVC (polyvinyl chloride), and latex (natural rubber)..
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