At normal or regular doses, benzodiazepines relieve anxiety and insomnia. Sometimes, people taking benzodiazepines may feel drowsy or dizzy.
This side effect can be more pronounced with increased doses.
Further benzodiazepines (triazolam and lorazepam) reduced defenses, escapes and attacks only at doses that suppressed most of the remaining activities as well.
Thus, the nine benzodiazepines tested exhibited different profiles of action in the present study.
Alprazolam, oxazepam and diazepam appeared least sedative, while triazolam and lorazepam were most sedative.
A few of the most popularly prescribed sleep aids fall into the family of pharmaceuticals called, benzodiazepines.
Sedatives encompass a wide variety of drugs with different mechanisms of action that can induce depression of the central nervous system (CNS).
In the first part of the 20th century, the pharmacotherapy of anxiety and insomnia relied on barbiturates, which were replaced with benzodiazepines as drugs of choice in the second part of the previous century.
Due to their safety and improved effectiveness, they have largely replaced barbiturates as drugs of choice in the treatment of anxiety.
At low doses, some benzodiazepines (alprazolam, oxazepam and diazepam) inhibited defenses, escapes, or attacks, but did not reduce other activities (social sniffing, walking, rearing), and actually increased most of them.
At comparable doses, other benzodiazepines (flunitrazepam, nitrazepam, clonazepam and chlordiazepoxide) stimulated only social sniffing, but reduced rearing or walking.
They also have hypnotic, anticonvulsant and muscle-relaxing activities, but do not exhibit analgesic action or antipsychotic activity.
The representatives of this group are: Nonbenzodiazepine “Z-drugs” sedative-hypnotics are drugs that differ in structure from benzodiazepines, but acts on a subset of the benzodiazepine receptor family known as BZ1.
Although some people may have a genetic tendency to become addicted to drugs, there is little doubt that environmental factors also play a significant role.